Lineage for d4i23a_ (4i23 A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2543502Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  7. 2543503Species Human (Homo sapiens) [TaxId:9606] [82796] (103 PDB entries)
    Uniprot P00533 702-1018
  8. 2543550Domain d4i23a_: 4i23 A: [194125]
    automated match to d1m14a_
    complexed with 1c9

Details for d4i23a_

PDB Entry: 4i23 (more details), 2.8 Å

PDB Description: Crystal structure of the wild-type EGFR kinase domain in complex with dacomitinib (soaked)
PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d4i23a_:

Sequence, based on SEQRES records: (download)

>d4i23a_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
sgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspk
ankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyl
lnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaegg
kvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlp
qppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptd
snfyralmdeedmddvvdadeyli

Sequence, based on observed residues (ATOM records): (download)

>d4i23a_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
sgeapnqallrilketefkkikvlgsgtvykglwipegekvkipvaikelatspkankei
ldeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcv
qiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpik
wmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppic
tidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpdmddvvdad
eyli

SCOPe Domain Coordinates for d4i23a_:

Click to download the PDB-style file with coordinates for d4i23a_.
(The format of our PDB-style files is described here.)

Timeline for d4i23a_: