SCOPe 2.06: Domain d4eosc1: 4eos C:1-296

Lineage for d4eosc1 (4eos C:1-296)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (374 PDB entries)
   Uniprot P24941

8. Domain d4eosc1: 4eos C:1-296 [194043]
   Other proteins in same PDB: d4eosa2, d4eosb1, d4eosb2, d4eosc2, d4eosd1, d4eosd2
   automated match to d3bhta_
   complexed with 1ro

Details for d4eosc1

PDB Entry: 4eos, 2.57 Å

PDB Description: Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor RO3306

PDB Compounds: (C:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4eosc1:

Sequence; same for both SEQRES and ATOM records:

>d4eosc1 d.144.1.7 (C:1-296) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Timeline for d4eosc1:

• d4eosc1 first appeared in SCOPe 2.02, called d4eosc_
  
• d4eosc1 was called d4eosc_ in SCOPe 2.05
  
• d4eosc1 appears in SCOPe 2.07
  
• d4eosc1 appears in the current release, SCOPe 2.08