SCOPe 2.03: Domain d4eona_: 4eon A:

Lineage for d4eona_ (4eon A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (335 PDB entries)
   Uniprot P24941

8. Domain d4eona_: 4eon A: [194042]
   Other proteins in same PDB: d4eonb1, d4eonb2, d4eond1, d4eond2
   automated match to d3bhta_
   complexed with 1ro, mg

Details for d4eona_

PDB Entry: 4eon, 2.4 Å

PDB Description: thr 160 phosphorylated cdk2 h84s, q85m, q131e - human cyclin a3 complex with the inhibitor ro3306

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4eona_:

Sequence; same for both SEQRES and ATOM records:

>d4eona_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
gsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkel
nhpnivklldvihtenklylvfeflsmdlkkfmdasaltgiplpliksylfqllqglafc
hshrvlhrdlkpenllintegaikladfglarafgvpvrtythevvtlwyrapeillgck
yystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykp
sfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d4eona_:

• d4eona_ first appeared in SCOPe 2.02
  
• d4eona_ appears in SCOPe 2.04
  
• d4eona_ appears in the current release, SCOPe 2.08, called d4eona1