SCOPe 2.02: Domain d4eopc_: 4eop C:

Lineage for d4eopc_ (4eop C:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (223 PDB entries)
   Uniprot P24941

8. Domain d4eopc_: 4eop C: [194037]
   automated match to d3bhta_
   complexed with 1ro, mg, sgm

Details for d4eopc_

PDB Entry: 4eop, 1.99 Å

PDB Description: Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with the inhibitor RO3306

PDB Compounds: (C:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4eopc_:

Sequence; same for both SEQRES and ATOM records:

>d4eopc_ d.144.1.7 (C:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpenllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Timeline for d4eopc_:

• d4eopc_ is new in SCOPe 2.02-stable
  
• d4eopc_ appears in SCOPe 2.03
  
• d4eopc_ appears in the current release, SCOPe 2.08, called d4eopc1