Lineage for d4eoia_ (4eoi A:)

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1929110Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1929111Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1929232Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1929749Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  7. 1929750Species Human (Homo sapiens) [TaxId:9606] [88856] (348 PDB entries)
    Uniprot P24941
  8. 1929942Domain d4eoia_: 4eoi A: [194036]
    Other proteins in same PDB: d4eoib1, d4eoib2, d4eoid1, d4eoid2
    automated match to d3bhta_
    complexed with 1ro, dms, sgm

Details for d4eoia_

PDB Entry: 4eoi (more details), 2 Å

PDB Description: Thr 160 phosphorylated CDK2 K89D, Q131E - human cyclin A3 complex with the inhibitor RO3306
PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4eoia_:

Sequence, based on SEQRES records: (download)

>d4eoia_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkdfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpenllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Sequence, based on observed residues (ATOM records): (download)

>d4eoia_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
smenfqkvekigegtygvvykarnkltgevvalkkirlegvpstaireisllkelnhpni
vklldvihtenklylvfeflhqdlkdfmdasaltgiplpliksylfqllqglafchshrv
lhrdlkpenllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyysta
vdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkw
arqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

SCOPe Domain Coordinates for d4eoia_:

Click to download the PDB-style file with coordinates for d4eoia_.
(The format of our PDB-style files is described here.)

Timeline for d4eoia_: