SCOPe 2.06: Domain d4hzrb_: 4hzr B:

Lineage for d4hzrb_ (4hzr B:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Activated CDC42 kinase 1, ACK1 [111200] (1 species)
   PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111201] (8 PDB entries)
   Uniprot Q07912 117-389

8. Domain d4hzrb_: 4hzr B: [194025]
   automated match to d1u54a_
   complexed with cl, edo, so4

Details for d4hzrb_

PDB Entry: 4hzr, 1.31 Å

PDB Description: Crystal structure of Ack1 kinase domain

PDB Compounds: (B:) Activated CDC42 kinase 1

SCOPe Domain Sequences for d4hzrb_:

Sequence, based on SEQRES records:

>d4hzrb_ d.144.1.7 (B:) Activated CDC42 kinase 1, ACK1 {Human (Homo sapiens) [TaxId: 9606]}
tcligekdlrlleklgdgsfgvvrrgewdapsgktvsvavkclkpdvlsqpeamddfire
vnamhsldhrnlirlygvvltppmkmvtelaplgslldrlrkhqghfllgtlsryavqva
egmgyleskrfihrdlaarnlllatrdlvkigdfglmralpqnddhyvmqehrkvpfawc
apeslktrtfshasdtwmfgvtlwemftygqepwiglngsqilhkidkegerlprpedcp
qdiynvmvqcwahkpedrptfvalrdflleaq

Sequence, based on observed residues (ATOM records):

>d4hzrb_ d.144.1.7 (B:) Activated CDC42 kinase 1, ACK1 {Human (Homo sapiens) [TaxId: 9606]}
tcligekdlrlleklgvvrrgewdapsgktvsvavkceamddfirevnamhsldhrnlir
lygvvltppmkmvtelaplgslldrlrkhqghfllgtlsryavqvaegmgyleskrfihr
dlaarnlllatrdlvkigdfglmralpqnddhyvmqehrkvpfawcapeslktrtfshas
dtwmfgvtlwemftygqepwiglngsqilhkidkegerlprpedcpqdiynvmvqcwahk
pedrptfvalrdflleaq

Timeline for d4hzrb_:

• d4hzrb_ first appeared in SCOPe 2.02
  
• d4hzrb_ appears in SCOPe 2.05
  
• d4hzrb_ appears in SCOPe 2.07
  
• d4hzrb_ appears in the current release, SCOPe 2.08