SCOPe 2.02: Domain d3u6ha_: 3u6h A:

Lineage for d3u6ha_ (3u6h A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (22 PDB entries)

8. Domain d3u6ha_: 3u6h A: [193806]
   automated match to d1r0pa_
   complexed with 03x

Details for d3u6ha_

PDB Entry: 3u6h, 2 Å

PDB Description: Crystal structure of c-Met in complex with pyrazolone inhibitor 26

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d3u6ha_:

Sequence, based on SEQRES records:

>d3u6ha_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
vhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavk
slnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfir
nethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglardmy
dkeyysvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntf
ditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyv
h

Sequence, based on observed residues (ATOM records):

>d3u6ha_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
vhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavk
slnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfir
nethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfgpvkwma
leslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeycpdp
lyevmlkcwhpkaemrpsfselvsrisaifstfigehyvh

Timeline for d3u6ha_:

• d3u6ha_ is new in SCOPe 2.02-stable
  
• d3u6ha_ appears in SCOPe 2.03
  
• d3u6ha_ appears in the current release, SCOPe 2.08