SCOPe 2.04: Domain d4ae6b_: 4ae6 B:

Lineage for d4ae6b_ (4ae6 B:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (13 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (490 PDB entries)

8. Domain d4ae6b_: 4ae6 B: [193754]
   automated match to d1cdka_
   complexed with act

Details for d4ae6b_

PDB Entry: 4ae6, 2.1 Å

PDB Description: A Crystal Structure of the Sperm Specific Isoform of Protein Kinase A (PKA) Subunit CalphaS Reveals a Binding Pocket for Hydrophobic Moieties

PDB Compounds: (B:) camp-dependent protein kinase catalytic subunit alpha 2

SCOPe Domain Sequences for d4ae6b_:

Sequence, based on SEQRES records:

>d4ae6b_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
keflakakedflkkwespaqntahldqferiktlgtgsfgrvmlvkhketgnhyamkild
kqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvpggemfshlrri
grfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvkgrt
wtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsgkv
rfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveapfi
pkfkgpgdtsnfddyeeeeirvsinekcgkefsef

Sequence, based on observed residues (ATOM records):

>d4ae6b_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
keflakakedflkkwespaqntahldqferiktlgtgsfgrvmlvkhketgnhyamkild
kqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvpggemfshlrri
grfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvkgrt
wtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsgkv
rfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveapfi
pkfeeeeirvsinekcgkefsef

Timeline for d4ae6b_:

• d4ae6b_ first appeared in SCOPe 2.02
  
• d4ae6b_ appears in SCOPe 2.03
  
• d4ae6b_ appears in SCOPe 2.05
  
• d4ae6b_ appears in the current release, SCOPe 2.08