SCOPe 2.08: Domain d4fv8a_: 4fv8 A:

Lineage for d4fv8a_ (4fv8 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d4fv8a_: 4fv8 A: [193548]
   automated match to d1erka_
   complexed with e63, edo, so4

Details for d4fv8a_

PDB Entry: 4fv8, 2 Å

PDB Description: Crystal Structure of the ERK2 complexed with E63

PDB Compounds: (A:) Mitogen-activated protein kinase 1

SCOPe Domain Sequences for d4fv8a_:

Sequence, based on SEQRES records:

>d4fv8a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqr
tlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhic
yflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgfltey
vatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgsp
sqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqa
lahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg

Sequence, based on observed residues (ATOM records):

>d4fv8a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqr
tlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhic
yflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvavatrwyrapeiml
nytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinlkarny
llslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydpsdep
iaeapfkfdmelddlpkeklkelifeetarfqpg

Timeline for d4fv8a_:

• d4fv8a_ first appeared in SCOPe 2.02
  
• d4fv8a_ appears in SCOPe 2.07