SCOPe 2.05: Domain d4ewoa_: 4ewo A:

Lineage for d4ewoa_ (4ewo A:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (258 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d4ewoa_: 4ewo A: [193413]
   automated match to d1fkna_
   complexed with 996

Details for d4ewoa_

PDB Entry: 4ewo, 1.8 Å

PDB Description: Design and synthesis of potent hydroxyethylamine (hea) bace-1 inhibitors

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4ewoa_:

Sequence, based on SEQRES records:

>d4ewoa_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
vemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlsst
yrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegil
glayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiiggi
dhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkk
vfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfrit
ilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsac
hvhdefrtaavegpfvtldmedcgyn

Sequence, based on observed residues (ATOM records):

>d4ewoa_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
vemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlsst
yrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegil
glayaeiarpddslepffdslvkqthvpnlfslqlcgagasvggsmiiggidhslytgsl
wytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksi
kaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrp
vedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrta
avegpfvtldmedcgyn

Timeline for d4ewoa_:

• d4ewoa_ first appeared in SCOPe 2.02
  
• d4ewoa_ appears in SCOPe 2.04
  
• d4ewoa_ appears in SCOPe 2.06
  
• d4ewoa_ appears in the current release, SCOPe 2.08