SCOPe 2.07: Domain d3vo3a_: 3vo3 A:

Lineage for d3vo3a_ (3vo3 A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56161] (25 PDB entries)

8. Domain d3vo3a_: 3vo3 A: [193217]
   automated match to d2p2ha_
   complexed with 0kf, edo

Details for d3vo3a_

PDB Entry: 3vo3, 1.52 Å

PDB Description: Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-b]pyridazine derivative

PDB Compounds: (A:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d3vo3a_:

Sequence, based on SEQRES records:

>d3vo3a_ d.144.1.7 (A:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
pldehcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlk
egathsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrsk
rnefvpykeapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknv
vkicdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifsl
gaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlg
nllqana

Sequence, based on observed residues (ATOM records):

>d3vo3a_ d.144.1.7 (A:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
pldehcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlk
egathsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrsk
rnefvpykdlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkic
dfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgasp
ypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllq
ana

Timeline for d3vo3a_:

• d3vo3a_ first appeared in SCOPe 2.02
  
• d3vo3a_ appears in SCOPe 2.06
  
• d3vo3a_ appears in the current release, SCOPe 2.08