SCOPe 2.08: Domain d4drhe1: 4drh E:2025-2112

Lineage for d4drhe1 (4drh E:2025-2112)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.24: Four-helical up-and-down bundle [47161] (29 superfamilies)
   core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

4. Superfamily a.24.7: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47212] (1 family)
   automatically mapped to Pfam PF08771

5. Family a.24.7.1: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47213] (2 proteins)

6. Protein mTOR FKBP12–rapamycin-binding (FRB) domain [47214] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47215] (11 PDB entries)

8. Domain d4drhe1: 4drh E:2025-2112 [193177]
   Other proteins in same PDB: d4drha_, d4drhb2, d4drhd_, d4drhe2
   automated match to d1aueb_
   complexed with rap, so4

Details for d4drhe1

PDB Entry: 4drh, 2.3 Å

PDB Description: Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR at low pH

PDB Compounds: (E:) Serine/threonine-protein kinase mTOR

SCOPe Domain Sequences for d4drhe1:

Sequence, based on SEQRES records:

>d4drhe1 a.24.7.1 (E:2025-2112) mTOR FKBP12–rapamycin-binding (FRB) domain {Human (Homo sapiens) [TaxId: 9606]}
emwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygrdlmeaqew
crkymksgnvkdltqawdlyyhvfrris

Sequence, based on observed residues (ATOM records):

>d4drhe1 a.24.7.1 (E:2025-2112) mTOR FKBP12–rapamycin-binding (FRB) domain {Human (Homo sapiens) [TaxId: 9606]}
emwhegleeasrlyfgernvkgmfevleplhammelketsfnqaygrdlmeaqewcrkym
ksgnvkdltqawdlyyhvfrris

Timeline for d4drhe1:

• d4drhe1 first appeared in SCOPe 2.02, called d4drhe_
  
• d4drhe1 appears in SCOPe 2.07