SCOPe 2.05: Domain d4jr0b_: 4jr0 B:

Lineage for d4jr0b_ (4jr0 B:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein Apopain (caspase-3, cpp32) [52131] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52132] (28 PDB entries)

8. Domain d4jr0b_: 4jr0 B: [193130]
   automated match to d2j30a_
   complexed with cl

Details for d4jr0b_

PDB Entry: 4jr0, 1.8 Å

PDB Description: human procaspase-3 bound to ac-devd-cmk

PDB Compounds: (B:) Procaspase-3

SCOPe Domain Sequences for d4jr0b_:

Sequence, based on SEQRES records:

>d4jr0b_ c.17.1.1 (B:) Apopain (caspase-3, cpp32) {Human (Homo sapiens) [TaxId: 9606]}
nadnsykmdypemglciiinnknfhkstgmtsrsgtdvdaanlretfrnlkyevrnkndl
treeivelmrdvskedhskrssfvcvllshgeegiifgtngpvdlkkitnffrgdrcrsl
tgkpklfiiqacrgteldcgietasgvdddmachkipveadflyaystapgyyswrnskd
gswfiqslcamlkqyadklefmhiltrvnrkvatefesfsfdatfhakkqipcivsmltk
elyfyh

Sequence, based on observed residues (ATOM records):

>d4jr0b_ c.17.1.1 (B:) Apopain (caspase-3, cpp32) {Human (Homo sapiens) [TaxId: 9606]}
nadnsykmdypemglciiinnknfhkstgmtsrsgtdvdaanlretfrnlkyevrnkndl
treeivelmrdvskedhskrssfvcvllshgeegiifgtngpvdlkkitnffrgdrcrsl
tgkpklfiiqacrgtipveadflyaystapgyyswrnskdgswfiqslcamlkqyadkle
fmhiltrvnrkvatefesfsfdatfhakkqipcivsmltkelyfyh

Timeline for d4jr0b_:

• d4jr0b_ first appeared in SCOPe 2.02
  
• d4jr0b_ appears in SCOPe 2.04
  
• d4jr0b_ is called d4jr0b1 in SCOPe 2.06
  
• d4jr0b_ appears in the current release, SCOPe 2.08, called d4jr0b1