SCOPe 2.05: Domain d4geoa_: 4geo A:

Lineage for d4geoa_ (4geo A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56130] (162 PDB entries)

8. Domain d4geoa_: 4geo A: [193068]
   automated match to d3itza_
   complexed with bog; mutant

Details for d4geoa_

PDB Entry: 4geo, 1.66 Å

PDB Description: p38a map kinase def-pocket penta mutant (m194a, l195a, h228a, i229a, y258a)

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d4geoa_:

Sequence, based on SEQRES records:

>d4geoa_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyva
trwyrapeiaanwmhynqtvdiwsvgcimaelltgrtlfpgtdaadqlklilrlvgtpga
ellkkissesarnaiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqala
hayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpp

Sequence, based on observed residues (ATOM records):

>d4geoa_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsvcaafdtktglrvavkklsrpfqsiihakrty
relrllkhmkhenviglldvftparsleefndvylvthlmgadlnnikltddhvqfliyq
ilrglkyihsadiihrdlkpsnlavnedcelkildfglatrwyrapeiaanwmhynqtvd
iwsvgcimaelltgrtlfpgtdaadqlklilrlvgtpgaellkkissesarnaiqsltqm
pkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdpddepvadpydq
sfesrdllidewksltydevisfvpp

Timeline for d4geoa_:

• d4geoa_ first appeared in SCOPe 2.02
  
• d4geoa_ appears in SCOPe 2.04
  
• d4geoa_ appears in SCOPe 2.06
  
• d4geoa_ appears in the current release, SCOPe 2.08