SCOPe 2.08: Domain d4elea1: 4ele A:1-162

Lineage for d4elea1 (4ele A:1-162)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.0: automated matches [191485] (1 protein)
   not a true family

6. Protein automated matches [190777] (28 species)
   not a true protein

7. Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [188674] (20 PDB entries)

8. Domain d4elea1: 4ele A:1-162 [192863]
   Other proteins in same PDB: d4elea2, d4eleb2, d4elec2, d4eled2, d4elee2, d4elef2, d4eleg2, d4eleh2
   automated match to d3fl8a_
   complexed with 31i, ca, cl

Details for d4elea1

PDB Entry: 4ele, 2.35 Å

PDB Description: Structure-activity relationship guides enantiomeric preference among potent inhibitors of B. anthracis dihydrofolate reductase

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d4elea1:

Sequence; same for both SEQRES and ATOM records:

>d4elea1 c.71.1.0 (A:1-162) automated matches {Anthrax bacillus (Bacillus anthracis) [TaxId: 1392]}
mivsfmvamdenrvigkdnnlpwrlpselqyvkkttmghplimgrknyeaigrplpgrrn
iivtrnegyhvegcevahsveevfelckneeeififggaqiydlflpyvdklyitkihha
fegdtffpemdmtnwkevfvekgltdeknpytyyyhvyekqq

Timeline for d4elea1:

• d4elea1 first appeared in SCOPe 2.02, called d4elea_
  
• d4elea1 appears in SCOPe 2.07