SCOPe 2.02: Domain d2xkwb_: 2xkw B:

Lineage for d2xkwb_ (2xkw B:)

1. Root: SCOPe 2.02

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48525] (76 PDB entries)
   Uniprot P37231 232-505

8. Domain d2xkwb_: 2xkw B: [191836]
   automated match to d3prga_
   complexed with epe, p1b, pe4

Details for d2xkwb_

PDB Entry: 2xkw, 2.02 Å

PDB Description: ligand binding domain of human ppar-gamma in complex with the agonist pioglitazone

PDB Compounds: (B:) Peroxisome proliferator-activated receptor gamma

SCOPe Domain Sequences for d2xkwb_:

Sequence, based on SEQRES records:

>d2xkwb_ a.123.1.1 (B:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
esadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikfkh
itplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheii
ytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlai
fiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqiv
tehvqllqvikktetdmslhpllqeiyk

Sequence, based on observed residues (ATOM records):

>d2xkwb_ a.123.1.1 (B:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
esadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikfkh
itevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlasl
mnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiaviil
sgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqll
qvikktehpllqeiyk

Timeline for d2xkwb_:

• d2xkwb_ is new in SCOPe 2.02-stable
  
• d2xkwb_ appears in SCOPe 2.03
  
• d2xkwb_ appears in the current release, SCOPe 2.08