SCOP 1.65: Domain d1e8ya1: 1e8y A:525-725

Lineage for d1e8ya1 (1e8y A:525-725)

1. Root: SCOP 1.65

2. Class a: All alpha proteins [46456] (179 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (17 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.1: ARM repeat [48371] (13 families)

5. Family a.118.1.6: Phoshoinositide 3-kinase (PI3K) helical domain [48399] (1 protein)
   this is a repeat family; one repeat unit is 1e8y A:598-635 found in domain

6. Protein Phoshoinositide 3-kinase (PI3K) helical domain [48400] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48402] (3 PDB entries)

8. Domain d1e8ya1: 1e8y A:525-725 [19152]
   Other proteins in same PDB: d1e8ya2, d1e8ya3, d1e8ya4
   mutant

Details for d1e8ya1

PDB Entry: 1e8y, 2 Å

PDB Description: structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine

SCOP Domain Sequences for d1e8ya1:

Sequence, based on SEQRES records:

>d1e8ya1 a.118.1.6 (A:525-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens)}
hpialpkhqptpdpegdrvraempnqlrkqleaiiatdplnpltaedkellwhfryeslk
hpkaypklfssvkwgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraia
vqklesledddvlhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseia
qsrhyqqrfavileaylrgcg

Sequence, based on observed residues (ATOM records):

>d1e8ya1 a.118.1.6 (A:525-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens)}
hpiaraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwg
qqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhy
llqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavilea
ylrgcg

Timeline for d1e8ya1:

• d1e8ya1 first appeared (with stable ids) in SCOP 1.55
  
• d1e8ya1 appears in SCOP 1.63
  
• d1e8ya1 appears in SCOP 1.67
  
• d1e8ya1 appears in the current release, SCOPe 2.08