SCOPe 2.08: Domain d1siga1: 1sig A:114-446

Lineage for d1siga1 (1sig A:114-446)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.177: Sigma2 domain of RNA polymerase sigma factors [88945] (1 superfamily)
   multihelical; consists of a conserved 4-helical core and a variable insert subdomain

4. Superfamily a.177.1: Sigma2 domain of RNA polymerase sigma factors [88946] (2 families)

5. Family a.177.1.1: Sigma2 domain of RNA polymerase sigma factors [88947] (6 proteins)

6. Protein Sigma70 [88948] (2 species)

7. Species Escherichia coli [TaxId:562] [48332] (2 PDB entries)
   Uniprot P00579 546-613

8. Domain d1siga1: 1sig A:114-446 [19068]
   Other proteins in same PDB: d1siga2
   sigma2 domain only with a large insert subdomain
   has additional subdomain(s) that are not in the common domain

Details for d1siga1

PDB Entry: 1sig, 2.6 Å

PDB Description: crystal structure of a sigma70 subunit fragment from escherichia coli rna polymerase

PDB Compounds: (A:) RNA polymerase primary sigma factor

SCOPe Domain Sequences for d1siga1:

Sequence, based on SEQRES records:

>d1siga1 a.177.1.1 (A:114-446) Sigma70 {Escherichia coli [TaxId: 562]}
egeidiakriedginqvqcsvaeypeaitylleqynrveaeearlsdlitgfvdpnaeed
laptathvgselsqedldddededeedgdddsadddnsidpelarekfaelraqyvvtrd
tikakgrshataqeeilklsevfkqfrlvpkqfdylvnsmrvmmdrvrtqerlimklcve
qckmpkknfitlftgnetsdtwfnaaiamnkpwseklhdvseevhralqklqqieeetgl
tieqvkdinrrmsigeakarrakkemveanlrlvisiakkytnrglqfldliqegniglm
kavdkfeyrrgykfstyatwwirqaitrsiadq

Sequence, based on observed residues (ATOM records):

>d1siga1 a.177.1.1 (A:114-446) Sigma70 {Escherichia coli [TaxId: 562]}
egeidiakriedginqvqcsvaeypeaitylleqynrveaeearlsdlitgfvddlapta
thvgselsqedldidpelarekfaelraqyvvtrdtikahataqeeilklsevfkqfrlv
pkqfdylvnsmrvmmdrvrtqerlimklcveqckmpkknfitlftgnetsdtwfnaaiam
nkpwseklhdvseevhralqklqqieeetgltieqvkdinrrmsigeakarrakkemvea
nlrlvisiakkytnrglqfldliqegniglmkavdkfeyrrgykfstyatwwirqaitrs
iadq

Timeline for d1siga1:

• d1siga1 first appeared (with stable ids) in SCOP 1.55, called d1sig__
  
• d1siga1 was called d1siga_ in SCOPe 2.07