SCOPe 2.07: Domain d1fmia1: 1fmi A:243-697

Lineage for d1fmia1 (1fmi A:243-697)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.102: alpha/alpha toroid [48207] (6 superfamilies)
   multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies

4. Superfamily a.102.2: Seven-hairpin glycosidases [48225] (1 family)
   automatically mapped to Pfam PF01532

5. Family a.102.2.1: Class I alpha-1;2-mannosidase, catalytic domain [48226] (1 protein)

6. Protein Class I alpha-1;2-mannosidase, catalytic domain [48227] (5 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48229] (6 PDB entries)

8. Domain d1fmia1: 1fmi A:243-697 [18846]
   Other proteins in same PDB: d1fmia2
   complexed with ca, so4

Details for d1fmia1

PDB Entry: 1fmi, 1.9 Å

PDB Description: crystal structure of human class i alpha1,2-mannosidase

PDB Compounds: (A:) endoplasmic reticulum alpha-mannosidase I

SCOPe Domain Sequences for d1fmia1:

Sequence, based on SEQRES records:

>d1fmia1 a.102.2.1 (A:243-697) Class I alpha-1;2-mannosidase, catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
pvhlnyrqkgvidvflhawkgyrkfawghdelkpvsrsfsewfglgltlidaldtmwilg
lrkefeearkwvskklhfekdvdvnlfestirilggllsayhlsgdslflrkaedfgnrl
mpafrtpskipysdvnigtgvahpprwtsdstvaevtsiqlefrelsrltgdkkfqeave
kvtqhihglsgkkdglvpmfinthsglfthlgvftlgaradsyyeyllkqwiqggkqetq
lledyveaiegvrthllrhsepskltfvgelahgrfsakmdhlvcflpgtlalgvyhglp
ashmelaqelmetcyqmnrqmetglspeivhfnlypqpgrrdvevkpadrhnllrpetve
slfylyrvtgdrkyqdwgweilqsfsrftrvpsggyssinnvqdpqkpeprdkmesfflg
etlkylfllfsddpnllsldayvfnteahplpiwt

Sequence, based on observed residues (ATOM records):

>d1fmia1 a.102.2.1 (A:243-697) Class I alpha-1;2-mannosidase, catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
pvhlnyrqkgvidvflhawkgyrkfawghdelkpvsrsfsewfglgltlidaldtmwilg
lrkefeearkwvskklhfekdvdvnlfestirilggllsayhlsgdslflrkaedfgnrl
mpafrtpskipysdvnigtgvahpprsdstvaevtsiqlefrelsrltgdkkfqeavekv
tqhihglsgkkdglvpmfinthsglfthlgvftlgaradsyyeyllkqwiqggkqetqll
edyveaiegvrthllrhsepskltfvgelahgrfsakmdhlvcflpgtlalgvyhglpas
hmelaqelmetcyqmnrqmetglspeivhfnlypqpgrrdvevkpadrhnllrpetvesl
fylyrvtgdrkyqdwgweilqsfsrftrvpsggyssinnvqdpqkpeprdkmesfflget
lkylfllfsddpnllsldayvfnteahplpiwt

Timeline for d1fmia1:

• d1fmia1 first appeared (with stable ids) in SCOP 1.55, called d1fmia_
  
• d1fmia1 appears in SCOPe 2.06
  
• d1fmia1 appears in the current release, SCOPe 2.08