SCOPe 2.08: Domain d4coxd1: 4cox D:74-583

Lineage for d4coxd1 (4cox D:74-583)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.93: Heme-dependent peroxidases [48112] (1 superfamily)
   multihelical; consists of two all-alpha domains

4. Superfamily a.93.1: Heme-dependent peroxidases [48113] (4 families)

5. Family a.93.1.2: Myeloperoxidase-like [48132] (3 proteins)

6. Protein Prostaglandin H2 synthase [48136] (2 species)
   contains EGF-like module

7. Species Mouse (Mus musculus) [TaxId:10090] [48138] (13 PDB entries)

8. Domain d4coxd1: 4cox D:74-583 [18725]
   Other proteins in same PDB: d4coxa2, d4coxb2, d4coxc2, d4coxd2
   complexed with hem, imn, nag

Details for d4coxd1

PDB Entry: 4cox, 2.9 Å

PDB Description: cyclooxygenase-2 (prostaglandin synthase-2) complexed with a non- selective inhibitor, indomethacin

PDB Compounds: (D:) cyclooxygenase-2

SCOPe Domain Sequences for d4coxd1:

Sequence; same for both SEQRES and ATOM records:

>d4coxd1 a.93.1.2 (D:74-583) Prostaglandin H2 synthase {Mouse (Mus musculus) [TaxId: 10090]}
fltriklllkptpntvhyilthfkgvwnivnnipflrslimkyvltsrsylidspptynv
hygyksweafsnlsyytralppvaddcptpmgvkgnkelpdskevlekvllrrefipdpq
gsnmmfaffaqhfthqffktdhkrgpgftrglghgvdlnhiygetldrqhklrlfkdgkl
kyqviggevypptvkdtqvemiypphipenlqfavgqevfglvpglmmyatiwlrehqrv
cdilkqehpewgdeqlfqtskliligetikiviedyvqhlsgyhfklkfdpellfnqqfq
yqnriasefntlyhwhpllpdtfniedqeysfkqflynnsillehgltqfvesftrqiag
rvaggrnvpiavqavakasidqsremkyqslneyrkrfslkpytsfeeltgekemaaelk
alysdidvmelypallvekprpdaifgetmvelgapfslkglmgnpicspqywkpstfgg
evgfkiintasiqslicnnvkgcpftsfnvq

Timeline for d4coxd1:

• d4coxd1 first appeared (with stable ids) in SCOP 1.55
  
• d4coxd1 appears in SCOPe 2.07