SCOPe 2.08: Domain d1ptha1: 1pth A:74-583

Lineage for d1ptha1 (1pth A:74-583)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.93: Heme-dependent peroxidases [48112] (1 superfamily)
   multihelical; consists of two all-alpha domains

4. Superfamily a.93.1: Heme-dependent peroxidases [48113] (4 families)

5. Family a.93.1.2: Myeloperoxidase-like [48132] (3 proteins)

6. Protein Prostaglandin H2 synthase [48136] (2 species)
   contains EGF-like module

7. Species Sheep (Ovis aries) [TaxId:9940] [48137] (23 PDB entries)
   Uniprot P05979 32-584

8. Domain d1ptha1: 1pth A:74-583 [18705]
   Other proteins in same PDB: d1ptha2, d1pthb2
   complexed with bog, hem, nag, sal

Details for d1ptha1

PDB Entry: 1pth, 3.4 Å

PDB Description: the structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin h2 synthase

PDB Compounds: (A:) prostaglandin h2 synthase-1

SCOPe Domain Sequences for d1ptha1:

Sequence; same for both SEQRES and ATOM records:

>d1ptha1 a.93.1.2 (A:74-583) Prostaglandin H2 synthase {Sheep (Ovis aries) [TaxId: 9940]}
iwtwlrttlrpspsfihfllthgrwlwdfvnatfirdtlmrlvltvrsnlipspptynia
hdyiswesfsnvsyytrilpsvprdcptpmgtkgkkqlpdaeflsrrfllrrkfipdpqg
tnlmfaffaqhfthqffktsgkmgpgftkalghgvdlghiygdnlerqyqlrlfkdgklk
yqmlngevyppsveeapvlmhyprgippqsqmavgqevfgllpglmlyatiwlrehnrvc
dllkaehptwgdeqlfqtarliligetikivieeyvqqlsgyflqlkfdpellfgaqfqy
rnriamefnqlyhwhplmpdsfrvgpqdysyeqflfntsmlvdygvealvdafsrqpagr
igggrnidhhilhvavdvikesrvlrlqpfneyrkrfgmkpytsfqeltgekemaaelee
lygdidalefypglllekchpnsifgesmiemgapfslkgllgnpicspeywkastfgge
vgfnlvktatlkklvclntktcpyvsfhvp

Timeline for d1ptha1:

• d1ptha1 first appeared (with stable ids) in SCOP 1.55, called d1pth_1
  
• d1ptha1 appears in SCOPe 2.07