SCOPe 2.08: Domain d3v6ra_: 3v6r A:

Lineage for d3v6ra_ (3v6r A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-jun N-terminal kinase (jnk3s) [56137] (1 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56138] (50 PDB entries)

8. Domain d3v6ra_: 3v6r A: [186460]
   automated match to d1jnka_
   complexed with cqq

Details for d3v6ra_

PDB Entry: 3v6r, 2.6 Å

PDB Description: Discovery of potent and selective covalent inhibitors of JNK

PDB Compounds: (A:) Mitogen-activated protein kinase 10

SCOPe Domain Sequences for d3v6ra_:

Sequence, based on SEQRES records:

>d3v6ra_ d.144.1.7 (A:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
dnqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqth
akrayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhe
rmsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsfmmtpyv
vtryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcp
efmkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidp
akrisvddalqhpyinvwydpaeveapppqiydkqlderehtieewkeliykevmns

Sequence, based on observed residues (ATOM records):

>d3v6ra_ d.144.1.7 (A:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
dnqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqth
akrayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhe
rmsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsfmmvtry
yrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmk
klqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpakri
svddalqhpyinvwydpaeveapppqiqlderehtieewkeliykevmns

Timeline for d3v6ra_:

• d3v6ra_ first appeared in SCOPe 2.01
  
• d3v6ra_ appears in SCOPe 2.07