SCOPe 2.08: Domain d3u6ac1: 3u6a C:-3-385

Lineage for d3u6ac1 (3u6a C:-3-385)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d3u6ac1: 3u6a C:-3-385 [186095]
   Other proteins in same PDB: d3u6ac2
   automated match to d1fkna_
   complexed with 18p, so4

Details for d3u6ac1

PDB Entry: 3u6a, 2.2 Å

PDB Description: Rational Design and Synthesis of Aminopiperazinones as Beta Secretase (BACE) Inhibitors

PDB Compounds: (C:) Beta-secretase 1

SCOPe Domain Sequences for d3u6ac1:

Sequence, based on SEQRES records:

>d3u6ac1 b.50.1.2 (C:-3-385) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyn

Sequence, based on observed residues (ATOM records):

>d3u6ac1 b.50.1.2 (C:-3-385) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplasvggsmiiggidhs
lytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfe
aavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilp
qqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvh
defrtaavegpfvtldmedcgyn

Timeline for d3u6ac1:

• d3u6ac1 first appeared in SCOPe 2.01, called d3u6ac_
  
• d3u6ac1 appears in SCOPe 2.07