Lineage for d3tu1a_ (3tu1 A:)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1998383Fold a.42: SWIB/MDM2 domain [47591] (1 superfamily)
    core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
    duplication: consists of two structural repeats
  4. 1998384Superfamily a.42.1: SWIB/MDM2 domain [47592] (2 families) (S)
    binds to the transactivation domain of human p53
  5. 1998385Family a.42.1.1: SWIB/MDM2 domain [47593] (5 proteins)
    Pfam PF02201
  6. 1998392Protein MDM2 [47594] (2 species)
  7. 1998410Species Human (Homo sapiens) [TaxId:9606] [47596] (59 PDB entries)
  8. 1998420Domain d3tu1a_: 3tu1 A: [185951]
    automated match to d1rv1a_
    complexed with 07g

Details for d3tu1a_

PDB Entry: 3tu1 (more details), 1.6 Å

PDB Description: exhaustive fluorine scanning towards potent p53-mdm2 antagonist
PDB Compounds: (A:) E3 ubiquitin-protein ligase Mdm2

SCOPe Domain Sequences for d3tu1a_:

Sequence; same for both SEQRES and ATOM records: (download)

>d3tu1a_ a.42.1.1 (A:) MDM2 {Human (Homo sapiens) [TaxId: 9606]}
qipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivyc
sndllgdlfgvpsfsvkehrkiytmiyrnlvvv

SCOPe Domain Coordinates for d3tu1a_:

Click to download the PDB-style file with coordinates for d3tu1a_.
(The format of our PDB-style files is described here.)

Timeline for d3tu1a_: