Lineage for d3tfqd1 (3tfq D:24-284)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2426096Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2426097Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2426443Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 2426470Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 2426486Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
    Uniprot P28845
  8. 2426493Domain d3tfqd1: 3tfq D:24-284 [185816]
    Other proteins in same PDB: d3tfqb2, d3tfqd2
    automated match to d1xu9a_
    complexed with 07m, gol, nap; mutant

Details for d3tfqd1

PDB Entry: 3tfq (more details), 1.8 Å

PDB Description: crystal structure of 11b-hsd1 double mutant (l262r, f278e) complexed with 8-{[(2-cyanopyridin-3-yl)methyl]sulfanyl}-6-hydroxy-3,4-dihydro-1h-pyrano[3,4-c]pyridine-5-carbonitrile
PDB Compounds: (D:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOPe Domain Sequences for d3tfqd1:

Sequence; same for both SEQRES and ATOM records: (download)

>d3tfqd1 c.2.1.2 (D:24-284) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3tfqd1:

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Timeline for d3tfqd1: