SCOPe 2.08: Domain d3si7d_: 3si7 D:

Lineage for d3si7d_ (3si7 D:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.12: ABC transporter ATPase domain-like [52686] (25 proteins)
   there are two additional subdomains inserted into the central core that has a RecA-like topology
   missing some secondary structures that made up less than one-third of the common domain
   

6. Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain [102378] (2 species)

7. Species Mouse (Mus musculus) [TaxId:10090] [102379] (9 PDB entries)
   Uniprot P26361 390-670

8. Domain d3si7d_: 3si7 D: [185413]
   Other proteins in same PDB: d3si7c2
   automated match to d1q3hc_
   complexed with act, atp, mg; mutant

Details for d3si7d_

PDB Entry: 3si7, 2.25 Å

PDB Description: The crystal structure of the NBD1 domain of the mouse CFTR protein, deltaF508 mutant

PDB Compounds: (D:) Cystic fibrosis transmembrane conductance regulator

SCOPe Domain Sequences for d3si7d_:

Sequence, based on SEQRES records:

>d3si7d_ c.37.1.12 (D:) Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain {Mouse (Mus musculus) [TaxId: 10090]}
tgiimenvtafweegfgellekvqqsngdrkhssdennvsfshlclvgnpvlkninlnie
kgemlaitgstgsgktsllmlilgeleasegiikhsgrvsfcsqfswimpgtikeniigv
sydeyryksvvkacqlqqditkfaeqdntvlgeggvtlsggqrarislaravykdadlyl
ldspfgyldvfteeqvfescvcklmanktrilvtskmehlrkadkililhqgssyfygtf
selqslrpdfssklmgydtfdqfteerrssiltetlrrfs

Sequence, based on observed residues (ATOM records):

>d3si7d_ c.37.1.12 (D:) Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain {Mouse (Mus musculus) [TaxId: 10090]}
tgiimenvtafweegfgellekshlclvgnpvlkninlniekgemlaitgstgsgktsll
mlilgeleasegiikhsgrvsfcsqfswimpgtikeniigvsydeyryksvvkacqlqqd
itkfaeqdntvlgeggvtlsggqrarislaravykdadlylldspfgyldvfteeqvfes
cvcklmanktrilvtskmehlrkadkililhqgssyfygtfselqslrpdfssklmgydt
fdqfteerrssiltetlrrfs

Timeline for d3si7d_:

• d3si7d_ first appeared in SCOPe 2.01
  
• d3si7d_ appears in SCOPe 2.07