SCOPe 2.01: Domain d3si2a_: 3si2 A:

Lineage for d3si2a_ (3si2 A:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

4. Superfamily c.56.5: Zn-dependent exopeptidases [53187] (10 families)
   core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest

5. Family c.56.5.8: Glutaminyl-peptide cyclotransferase-like [142532] (1 protein)
   part of Pfam PF04389

6. Protein Glutaminyl-peptide cyclotransferase, QPCT [142533] (2 species)
   Glutaminyl cyclase

7. Species Mouse (Mus musculus) [TaxId:10090] [189699] (2 PDB entries)

8. Domain d3si2a_: 3si2 A: [185409]
   automated match to d2afma1
   complexed with act, pbd, so4, zn

Details for d3si2a_

PDB Entry: 3si2, 1.8 Å

PDB Description: structure of glycosylated murine glutaminyl cyclase in presence of the inhibitor pq50 (pdbd150)

PDB Compounds: (A:) Glutaminyl-peptide cyclotransferase

SCOPe Domain Sequences for d3si2a_:

Sequence, based on SEQRES records:

>d3si2a_ c.56.5.8 (A:) Glutaminyl-peptide cyclotransferase, QPCT {Mouse (Mus musculus) [TaxId: 10090]}
awtqeknhhqpahlnssslqqvaegtsisemwqndlrpllierypgspgsysarqhimqr
iqrlqaewvvevdtflsrtpygyrsfsniistlnpeakrhlvlachydskyfprwdsrvf
vgatdsavpcammlelaraldkklhslkdvsgskpdlslqliffdgeeafhhwspqdsly
gsrhlaqkmassphppgsrgtnqldgmdllvlldligaanptfpnffpkttrwfnrlqai
ekelyelgllkdhslerkyfqnfgygniiqddhipflrkgvpvlhliaspfpevwhtmdd
neenlhastidnlnkiiqvfvleylhl

Sequence, based on observed residues (ATOM records):

>d3si2a_ c.56.5.8 (A:) Glutaminyl-peptide cyclotransferase, QPCT {Mouse (Mus musculus) [TaxId: 10090]}
awtqeknhhqpahlnssslqqvaegtsisemwqndlrpllierypgspgsysarqhimqr
iqrlqaewvvevdtflsrtpygyrsfsniistlnpeakrhlvlachydskyfprwdsrvf
vgatdsavpcammlelaraldkklhslkdpdlslqliffdgeeafhhwspqdslygsrhl
aqkmassphppgsrgtnqldgmdllvlldligaanptfpnffpkttrwfnrlqaiekely
elgllkdhslerkyfqnfgygniiqddhipflrkgvpvlhliaspfpevwhtmddneenl
hastidnlnkiiqvfvleylhl

Timeline for d3si2a_:

• d3si2a_ is new in SCOPe 2.01-stable
  
• d3si2a_ appears in SCOPe 2.02
  
• d3si2a_ appears in the current release, SCOPe 2.08