SCOPe 2.01: Domain d3rigb_: 3rig B:

Lineage for d3rigb_ (3rig B:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein automated matches [191258] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189817] (2 PDB entries)

8. Domain d3rigb_: 3rig B: [184983]
   automated match to d2b4ya1
   complexed with nhe, zn

Details for d3rigb_

PDB Entry: 3rig, 2 Å

PDB Description: sirt5 is an nad-dependent protein lysine demalonylase and desuccinylase

PDB Compounds: (B:) NAD-dependent deacetylase sirtuin-5

SCOPe Domain Sequences for d3rigb_:

Sequence, based on SEQRES records:

>d3rigb_ c.31.1.5 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ftarpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlatplaf
ahnpsrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagt
knlleihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeag
cggllrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpv
aefntettpatnrfrfhfqgpcgttlpeala

Sequence, based on observed residues (ATOM records):

>d3rigb_ c.31.1.5 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ftarpsssmadfrkffakakhiviisgaaggywrkwqaqdlatplafahnpsrvwefyhy
rrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagtknlleihgslfkt
rctscgvvaenykspicpalsgkgapepgtqdasipveklprceeagcggllrphvvwfg
enldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpvaefntettpatnr
frfhfqgpcgttlpeala

Timeline for d3rigb_:

• d3rigb_ is new in SCOPe 2.01-stable
  
• d3rigb_ appears in SCOPe 2.02
  
• d3rigb_ appears in the current release, SCOPe 2.08, called d3rigb1