SCOPe 2.01: Domain d3ri3b_: 3ri3 B:

Lineage for d3ri3b_ (3ri3 B:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein automated matches [190085] (29 species)
   not a true protein

7. Species Streptomyces coelicolor [TaxId:1902] [189970] (2 PDB entries)

8. Domain d3ri3b_: 3ri3 B: [184979]
   automated match to d1w4zb_
   complexed with emo, ndp; mutant

Details for d3ri3b_

PDB Entry: 3ri3, 2.29 Å

PDB Description: actinorhodin polyketide ketoreductase mutant p94l bound to nadph and the inhibitor emodin

PDB Compounds: (B:) ketoacyl reductase

SCOPe Domain Sequences for d3ri3b_:

Sequence, based on SEQRES records:

>d3ri3b_ c.2.1.2 (B:) automated matches {Streptomyces coelicolor [TaxId: 1902]}
rgshmatqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagve
adgrtcdvrsvpeiealvaavverygpvdvlvnnagrlgggataeladelwldvvetnlt
gvfrvtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglela
rtgitvnavcpgfvetpmaasvrehysdiwevsteeafdritarvpigryvqpsevaemv
ayligpgaaavtaqalnvcgglgny

Sequence, based on observed residues (ATOM records):

>d3ri3b_ c.2.1.2 (B:) automated matches {Streptomyces coelicolor [TaxId: 1902]}
rgshmatqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagve
adgrtcdvrsvpeiealvaavverygpvdvlvnnagrlgggataeladelwldvvetnlt
gvfrvtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglela
rtgitvnavcpgfvetpmaasvrehteeafdritarvpigryvqpsevaemvayligpga
aavtaqalnvcgglgny

Timeline for d3ri3b_:

• d3ri3b_ is new in SCOPe 2.01-stable
  
• d3ri3b_ appears in SCOPe 2.02
  
• d3ri3b_ appears in the current release, SCOPe 2.08, called d3ri3b1