Lineage for d3r1gb_ (3r1g B:)

  1. Root: SCOPe 2.04
  2. 1510239Class b: All beta proteins [48724] (176 folds)
  3. 1548217Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 1548218Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 1549490Family b.50.1.2: Pepsin-like [50646] (11 proteins)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 1549547Protein beta-secretase (memapsin) [50671] (1 species)
  7. 1549548Species Human (Homo sapiens) [TaxId:9606] [50672] (242 PDB entries)
    Uniprot P56817 58-446 ! Uniprot P56817 60-447
  8. 1549918Domain d3r1gb_: 3r1g B: [184774]
    Other proteins in same PDB: d3r1gl1, d3r1gl2
    automated match to d1fkna_

Details for d3r1gb_

PDB Entry: 3r1g (more details), 2.8 Å

PDB Description: Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody
PDB Compounds: (B:) Beta-secretase 1

SCOPe Domain Sequences for d3r1gb_:

Sequence, based on SEQRES records: (download)

>d3r1gb_ b.50.1.2 (B:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
srgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqr
qlsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsn
wegilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsm
iiggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnl
rlpkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnq
sfritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigf
avsachvhdefrtaavegpfvtldmedcgyni

Sequence, based on observed residues (ATOM records): (download)

>d3r1gb_ b.50.1.2 (B:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
srgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqr
qlsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsn
wegilglayaeiarpddslepffdslvkqthvpnlfslqlcgalasvggsmiiggidhsl
ytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfea
avksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpq
qylrpvvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdef
rtaavegpfvtldmedcgyni

SCOPe Domain Coordinates for d3r1gb_:

Click to download the PDB-style file with coordinates for d3r1gb_.
(The format of our PDB-style files is described here.)

Timeline for d3r1gb_: