Lineage for d3r1gb1 (3r1g B:57-447)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2058814Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2058815Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2060177Family b.50.1.2: Pepsin-like [50646] (11 protein domains)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 2060235Protein beta-secretase (memapsin) [50671] (1 species)
  7. 2060236Species Human (Homo sapiens) [TaxId:9606] [50672] (281 PDB entries)
    Uniprot P56817 58-446 ! Uniprot P56817 60-447
  8. 2060628Domain d3r1gb1: 3r1g B:57-447 [184774]
    Other proteins in same PDB: d3r1gb2, d3r1gl1, d3r1gl2
    automated match to d1fkna_

Details for d3r1gb1

PDB Entry: 3r1g (more details), 2.8 Å

PDB Description: Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody
PDB Compounds: (B:) Beta-secretase 1

SCOPe Domain Sequences for d3r1gb1:

Sequence, based on SEQRES records: (download)

>d3r1gb1 b.50.1.2 (B:57-447) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
rgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmi
iggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlr
lpkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqs
fritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfa
vsachvhdefrtaavegpfvtldmedcgyni

Sequence, based on observed residues (ATOM records): (download)

>d3r1gb1 b.50.1.2 (B:57-447) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
rgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgalasvggsmiiggidhsly
tgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaa
vksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqq
ylrpvvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefr
taavegpfvtldmedcgyni

SCOPe Domain Coordinates for d3r1gb1:

Click to download the PDB-style file with coordinates for d3r1gb1.
(The format of our PDB-style files is described here.)

Timeline for d3r1gb1:

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Domains from same chain:
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d3r1gb2