SCOPe 2.05: Domain d3qkda_: 3qkd A:

Lineage for d3qkda_ (3qkd A:)

1. Root: SCOPe 2.05

2. Class f: Membrane and cell surface proteins and peptides [56835] (57 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein Apoptosis regulator Bcl-xL [56856] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56857] (32 PDB entries)

8. Domain d3qkda_: 3qkd A: [184464]
   automated match to d1g5ja_
   complexed with cl, gol, hi0

Details for d3qkda_

PDB Entry: 3qkd, 2.02 Å

PDB Description: Crystal structure of Bcl-xL in complex with a Quinazoline sulfonamide inhibitor

PDB Compounds: (A:) Bcl-2-like protein 1

SCOPe Domain Sequences for d3qkda_:

Sequence, based on SEQRES records:

>d3qkda_ f.1.4.1 (A:) Apoptosis regulator Bcl-xL {Human (Homo sapiens) [TaxId: 9606]}
snrelvvdflsyklsqkgyswsqfsdveenrteapegteseavkqalreagdefelryrr
afsdltsqlhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlv
sriaawmatylndhlepwiqenggwdtfvelygn

Sequence, based on observed residues (ATOM records):

>d3qkda_ f.1.4.1 (A:) Apoptosis regulator Bcl-xL {Human (Homo sapiens) [TaxId: 9606]}
snrelvvdflsyklsqkgyswsqfsseavkqalreagdefelryrrafsdltsqlhitpg
tayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylndh
lepwiqenggwdtfvelygn

Timeline for d3qkda_:

• d3qkda_ first appeared in SCOPe 2.01
  
• d3qkda_ appears in SCOPe 2.04
  
• d3qkda_ appears in SCOPe 2.06
  
• d3qkda_ appears in the current release, SCOPe 2.08