SCOPe 2.02: Domain d3pp1a_: 3pp1 A:

Lineage for d3pp1a_ (3pp1 A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (293 PDB entries)

8. Domain d3pp1a_: 3pp1 A: [183918]
   automated match to d1s9ja_
   complexed with act, atp, izg, mg

Details for d3pp1a_

PDB Entry: 3pp1, 2.7 Å

PDB Description: crystal structure of the human mitogen-activated protein kinase kinase 1 (mek 1) in complex with ligand and mgatp

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d3pp1a_:

Sequence, based on SEQRES records:

>d3pp1a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
melkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhe
cnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltyl
rekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymsperlqgthy
svqsdiwsmglslvemavgrypipppdakelelmfgcqvegdaaetpprprtpgrplssy
gmdsrppmaifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhaf
ikrsdaeevdfagwlcstigln

Sequence, based on observed residues (ATOM records):

>d3pp1a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
melkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhe
cnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltyl
rekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymsperlqgthy
svqsdiwsmglslvemavgrypipppdakelelmfpmaifelldyivnepppklpsgvfs
lefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigln

Timeline for d3pp1a_:

• d3pp1a_ first appeared in SCOPe 2.01
  
• d3pp1a_ appears in SCOPe 2.03
  
• d3pp1a_ appears in the current release, SCOPe 2.08, called d3pp1a1