SCOPe 2.05: Domain d3pd0a_: 3pd0 A:

Lineage for d3pd0a_ (3pd0 A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein Apopain (caspase-3, cpp32) [52131] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52132] (28 PDB entries)

8. Domain d3pd0a_: 3pd0 A: [183657]
   automated match to d1nmqa_
   complexed with cl

Details for d3pd0a_

PDB Entry: 3pd0, 2 Å

PDB Description: Caspase-3 E246A

PDB Compounds: (A:) Caspase-3

SCOPe Domain Sequences for d3pd0a_:

Sequence, based on SEQRES records:

>d3pd0a_ c.17.1.1 (A:) Apopain (caspase-3, cpp32) {Human (Homo sapiens) [TaxId: 9606]}
sgisldnsykmdypemglciiinnknfhkstgmtsrsgtdvdaanlretfrnlkyevrnk
ndltreeivelmrdvskedhskrssfvcvllshgeegiifgtngpvdlkkitnffrgdrc
rsltgkpklfiiqacrgteldsgietdsgvdddmachkipveadflyaystapgyyswrn
skdgswfiqslcamlkqyadklefmhiltrvnrkvatafesfsfdatfhakkqipcivsm
ltkelyfyhh

Sequence, based on observed residues (ATOM records):

>d3pd0a_ c.17.1.1 (A:) Apopain (caspase-3, cpp32) {Human (Homo sapiens) [TaxId: 9606]}
sgisldnsykmdypemglciiinnknfhkstgmtsrsgtdvdaanlretfrnlkyevrnk
ndltreeivelmrdvskedhskrssfvcvllshgeegiifgtngpvdlkkitnffrgdrc
rsltgkpklfiiqacrgteldsgiekipveadflyaystapgyyswrnskdgswfiqslc
amlkqyadklefmhiltrvnrkvatafesfsfdatfhakkqipcivsmltkelyfyhh

Timeline for d3pd0a_:

• d3pd0a_ first appeared in SCOPe 2.01
  
• d3pd0a_ appears in SCOPe 2.04
  
• d3pd0a_ is called d3pd0a1 in SCOPe 2.06
  
• d3pd0a_ appears in the current release, SCOPe 2.08, called d3pd0a1