SCOPe 2.06: Domain d3obba2: 3obb A:1-162

Lineage for d3obba2 (3obb A:1-162)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (19 proteins)
   the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
   C-terminal domains also show some similarity

6. Protein Hydroxyisobutyrate dehydrogenase [102171] (4 species)

7. Species Pseudomonas aeruginosa [TaxId:287] [159424] (2 PDB entries)
   Uniprot Q9I5I6 1-162

8. Domain d3obba2: 3obb A:1-162 [182915]
   Other proteins in same PDB: d3obba1
   complexed with act, edo, epe

Details for d3obba2

PDB Entry: 3obb, 2.2 Å

PDB Description: crystal structure of a possible 3-hydroxyisobutyrate dehydrogenase from pseudomonas aeruginosa pao1

PDB Compounds: (A:) Probable 3-hydroxyisobutyrate dehydrogenase

SCOPe Domain Sequences for d3obba2:

Sequence, based on SEQRES records:

>d3obba2 c.2.1.6 (A:1-162) Hydroxyisobutyrate dehydrogenase {Pseudomonas aeruginosa [TaxId: 287]}
mkqiafiglghmgapmatnllkagyllnvfdlvqsavdglvaagasaarsardavqgadv
vismlpasqhveglyldddgllahiapgtlvlecstiaptsarkihaaarerglamldap
vsggtagaaagtltfmvggdaealekarplfeamgrnifhag

Sequence, based on observed residues (ATOM records):

>d3obba2 c.2.1.6 (A:1-162) Hydroxyisobutyrate dehydrogenase {Pseudomonas aeruginosa [TaxId: 287]}
mkqiafiglghmgapmatnllkagyllnvfdlvqsavdglvaagasaarsardavqgadv
vismlpasqhveglyldddgllahiaptlvlecstiaptsarkihaaarerglamldapv
sggtagaaagtltfmvggdaealekarplfeamgrnifhag

Timeline for d3obba2:

• d3obba2 first appeared in SCOPe 2.01
  
• d3obba2 appears in SCOPe 2.05
  
• d3obba2 appears in SCOPe 2.07
  
• d3obba2 appears in the current release, SCOPe 2.08