SCOPe 2.08: Domain d3o50b_: 3o50 B:

Lineage for d3o50b_ (3o50 B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Aurora-related kinase 1 (aurora-2) [90038] (1 species)
   OPK group; AIRK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [90039] (72 PDB entries)

8. Domain d3o50b_: 3o50 B: [182800]
   automated match to d1ol5a_
   complexed with lje

Details for d3o50b_

PDB Entry: 3o50, 2 Å

PDB Description: Crystal structure of benzamide 9 bound to AuroraA

PDB Compounds: (B:) cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6

SCOPe Domain Sequences for d3o50b_:

Sequence, based on SEQRES records:

>d3o50b_ d.144.1.7 (B:) Aurora-related kinase 1 (aurora-2) {Human (Homo sapiens) [TaxId: 9606]}
rqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiq
shlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanals
ychskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylppemiegrm
hdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllk
hnpsqrpmlrevlehpwitanssk

Sequence, based on observed residues (ATOM records):

>d3o50b_ d.144.1.7 (B:) Aurora-related kinase 1 (aurora-2) {Human (Homo sapiens) [TaxId: 9606]}
rqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiq
shlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanals
ychskrvihrdikpenlllgsagelkiadfttlcgtldylppemiedekvdlwslgvlcy
eflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkhnpsqrpmlrevleh
pwitanssk

Timeline for d3o50b_:

• d3o50b_ first appeared in SCOPe 2.01
  
• d3o50b_ appears in SCOPe 2.07