Lineage for d3nxxa_ (3nxx A:)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2477518Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2477519Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2477520Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2477723Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2477771Species Human (Homo sapiens) [TaxId:9606] [53607] (74 PDB entries)
  8. 2477796Domain d3nxxa_: 3nxx A: [182618]
    automated match to d1drfa_
    complexed with d2d, ndp

Details for d3nxxa_

PDB Entry: 3nxx (more details), 1.35 Å

PDB Description: preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e- and z-isomers of a series of 5-substituted 2,4-diaminofuro-2,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d3nxxa_:

Sequence; same for both SEQRES and ATOM records: (download)

>d3nxxa_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3nxxa_:

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Timeline for d3nxxa_: