Lineage for d3nxta_ (3nxt A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2137011Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2137059Species Human (Homo sapiens) [TaxId:9606] [53607] (63 PDB entries)
  8. 2137089Domain d3nxta_: 3nxt A: [182614]
    automated match to d1drfa_
    complexed with d2e, ndp, so4

Details for d3nxta_

PDB Entry: 3nxt (more details), 1.7 Å

PDB Description: Preferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for the E-and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2m,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d3nxta_:

Sequence; same for both SEQRES and ATOM records: (download)

>d3nxta_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3nxta_:

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(The format of our PDB-style files is described here.)

Timeline for d3nxta_: