SCOPe 2.08: Domain d3nw7a_: 3nw7 A:

Lineage for d3nw7a_ (3nw7 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Insulin-like growth factor 1 receptor [69825] (1 species)
   PTK group; InsR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69826] (18 PDB entries)

8. Domain d3nw7a_: 3nw7 A: [182591]
   automated match to d1m7na_
   complexed with lgv

Details for d3nw7a_

PDB Entry: 3nw7, 2.11 Å

PDB Description: Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked proline isostere inhibitor (34)

PDB Compounds: (A:) insulin-like growth factor 1 receptor

SCOPe Domain Sequences for d3nw7a_:

Sequence, based on SEQRES records:

>d3nw7a_ d.144.1.7 (A:) Insulin-like growth factor 1 receptor {Human (Homo sapiens) [TaxId: 9606]}
yvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmrerie
flneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpemennpvlap
pslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyy
rkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvm
egglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

Sequence, based on observed residues (ATOM records):

>d3nw7a_ d.144.1.7 (A:) Insulin-like growth factor 1 receptor {Human (Homo sapiens) [TaxId: 9606]}
yvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmrerie
flneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpemennpvlap
pslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyy
rkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmegg
lldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

Timeline for d3nw7a_:

• d3nw7a_ first appeared in SCOPe 2.01
  
• d3nw7a_ appears in SCOPe 2.07