Lineage for d3ntza_ (3ntz A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2137011Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2137059Species Human (Homo sapiens) [TaxId:9606] [53607] (63 PDB entries)
  8. 2137071Domain d3ntza_: 3ntz A: [182542]
    automated match to d1drfa_
    complexed with 3tz, ndp, so4

Details for d3ntza_

PDB Entry: 3ntz (more details), 1.35 Å

PDB Description: Design, Synthesis, Biological Evaluation and X-ray Crystal Structures of Novel Classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d3ntza_:

Sequence; same for both SEQRES and ATOM records: (download)

>d3ntza_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3ntza_:

Click to download the PDB-style file with coordinates for d3ntza_.
(The format of our PDB-style files is described here.)

Timeline for d3ntza_: