SCOPe 2.05: Domain d3mj1a_: 3mj1 A:

Lineage for d3mj1a_ (3mj1 A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
   PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111195] (33 PDB entries)
   Uniprot Q08881 357-619

8. Domain d3mj1a_: 3mj1 A: [181296]
   automated match to d1sm2a_
   complexed with 614

Details for d3mj1a_

PDB Entry: 3mj1, 1.72 Å

PDB Description: X-ray crystal structure of ITK complexed with inhibitor RO5191614

PDB Compounds: (A:) Tyrosine-protein kinase ITK/TSK

SCOPe Domain Sequences for d3mj1a_:

Sequence, based on SEQRES records:

>d3mj1a_ d.144.1.7 (A:) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
gsvidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmkls
hpklvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayle
easvihrdlaarnclvgenqvikvsdfgmtrfvlddqytsstgtkfpvkwaspevfsfsr
yssksdvwsfgvlmwevfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhc
wkerpedrpafsrllrqlaai

Sequence, based on observed residues (ATOM records):

>d3mj1a_ d.144.1.7 (A:) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
gsvidpseltfvqeigsgglvhlgywlnkdkvaiktieeaevmmklshpklvqlygvcle
qapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeasvihrdlaarn
clvgenqvikvsdfpvkwaspevfsfsryssksdvwsfgvlmwevfsegkipyersnsev
vedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrqlaai

Timeline for d3mj1a_:

• d3mj1a_ first appeared in SCOPe 2.01
  
• d3mj1a_ appears in SCOPe 2.04
  
• d3mj1a_ is called d3mj1a1 in SCOPe 2.06
  
• d3mj1a_ appears in the current release, SCOPe 2.08, called d3mj1a1