SCOPe 2.02: Domain d3miya_: 3miy A:

Lineage for d3miya_ (3miy A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (293 PDB entries)

8. Domain d3miya_: 3miy A: [181293]
   automated match to d1sm2a_
   complexed with b49

Details for d3miya_

PDB Entry: 3miy, 1.67 Å

PDB Description: x-ray crystal structure of itk complexed with sunitinib

PDB Compounds: (A:) Tyrosine-protein kinase ITK/TSK

SCOPe Domain Sequences for d3miya_:

Sequence, based on SEQRES records:

>d3miya_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gsvidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmkls
hpklvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayle
easvihrdlaarnclvgenqvikvsdfgmtrfvlddqytsstgtkfpvkwaspevfsfsr
yssksdvwsfgvlmwevfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhc
wkerpedrpafsrllrqlaaiaasg

Sequence, based on observed residues (ATOM records):

>d3miya_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gsvidpseltfvqeigsgglvhlgywlnkdkvaiktiseedfieeaevmmklshpklvql
ygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeasvihr
dlaarnclvgenqvikvsdfpvkwaspevfsfsryssksdvwsfgvlmwevfsegkipye
nrsnsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrqlaaiaasg

Timeline for d3miya_:

• d3miya_ first appeared in SCOPe 2.01
  
• d3miya_ appears in SCOPe 2.03
  
• d3miya_ appears in the current release, SCOPe 2.08, called d3miya1