SCOPe 2.08: Domain d3miya1: 3miy A:357-619

Lineage for d3miya1 (3miy A:357-619)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
   PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111195] (33 PDB entries)
   Uniprot Q08881 357-619

8. Domain d3miya1: 3miy A:357-619 [181293]
   Other proteins in same PDB: d3miya2, d3miyb2
   automated match to d1sm2a_
   complexed with b49

Details for d3miya1

PDB Entry: 3miy, 1.67 Å

PDB Description: x-ray crystal structure of itk complexed with sunitinib

PDB Compounds: (A:) Tyrosine-protein kinase ITK/TSK

SCOPe Domain Sequences for d3miya1:

Sequence, based on SEQRES records:

>d3miya1 d.144.1.7 (A:357-619) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
vidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmklshp
klvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleea
svihrdlaarnclvgenqvikvsdfgmtrfvlddqytsstgtkfpvkwaspevfsfsrys
sksdvwsfgvlmwevfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhcwk
erpedrpafsrllrqlaaiaasg

Sequence, based on observed residues (ATOM records):

>d3miya1 d.144.1.7 (A:357-619) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
vidpseltfvqeigsgglvhlgywlnkdkvaiktiseedfieeaevmmklshpklvqlyg
vcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeasvihrdl
aarnclvgenqvikvsdfpvkwaspevfsfsryssksdvwsfgvlmwevfsegkipyenr
snsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrqlaaiaasg

Timeline for d3miya1:

• d3miya1 first appeared in SCOPe 2.01, called d3miya_
  
• d3miya1 appears in SCOPe 2.07