SCOPe 2.01: Domain d3lbla_: 3lbl A:

Lineage for d3lbla_ (3lbl A:)

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.42: SWIB/MDM2 domain [47591] (1 superfamily)
   core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
   duplication: consists of two structural repeats

4. Superfamily a.42.1: SWIB/MDM2 domain [47592] (2 families)
   binds to the transactivation domain of human p53

5. Family a.42.1.1: SWIB/MDM2 domain [47593] (4 proteins)
   Pfam PF02201

6. Protein MDM2 [47594] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47596] (14 PDB entries)

8. Domain d3lbla_: 3lbl A: [180164]
   automated match to d1rv1a_
   complexed with mi6

Details for d3lbla_

PDB Entry: 3lbl, 1.6 Å

PDB Description: structure of human mdm2 protein in complex with mi-63-analog

PDB Compounds: (A:) E3 ubiquitin-protein ligase Mdm2

SCOPe Domain Sequences for d3lbla_:

Sequence; same for both SEQRES and ATOM records:

>d3lbla_ a.42.1.1 (A:) MDM2 {Human (Homo sapiens) [TaxId: 9606]}
mqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivy
csndllgdlfgvpsfsvkehrkiytmiyrnlvvv

Timeline for d3lbla_:

• d3lbla_ is new in SCOPe 2.01-stable
  
• d3lbla_ appears in SCOPe 2.02
  
• d3lbla_ appears in the current release, SCOPe 2.08, called d3lbla1