Lineage for d3l8xa_ (3l8x A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2544248Protein MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  7. 2544249Species Human (Homo sapiens) [TaxId:9606] [56130] (198 PDB entries)
  8. 2544409Domain d3l8xa_: 3l8x A: [180096]
    automated match to d2rg6a_
    complexed with n4d

Details for d3l8xa_

PDB Entry: 3l8x (more details), 2.4 Å

PDB Description: P38 alpha kinase complexed with a pyrazolo-pyrimidine based inhibitor
PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d3l8xa_:

Sequence, based on SEQRES records: (download)

>d3l8xa_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyv
atrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpg
aellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqal
ahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Sequence, based on observed residues (ATOM records): (download)

>d3l8xa_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
erptfyrqelnktiwevperyqnlspvsvcaafdtktglrvavkklsrpfqsiihakrty
relrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkqkltddhvqfl
iyqilrglkyihsadiihrdlkpsnlavnedcelkildfglaratrwyrapeimnqtvdi
wsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkissesarnyiqsltqmp
kmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdpddepvadpydqs
fesrdllidewksltydevisfvppp

SCOPe Domain Coordinates for d3l8xa_:

Click to download the PDB-style file with coordinates for d3l8xa_.
(The format of our PDB-style files is described here.)

Timeline for d3l8xa_: