Lineage for d3kn0b_ (3kn0 B:)

  1. Root: SCOPe 2.02
  2. 1103260Class b: All beta proteins [48724] (174 folds)
  3. 1130027Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 1130028Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 1131149Family b.50.1.2: Pepsin-like [50646] (11 proteins)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 1131206Protein beta-secretase (memapsin) [50671] (1 species)
  7. 1131207Species Human (Homo sapiens) [TaxId:9606] [50672] (139 PDB entries)
    Uniprot P56817 58-446 ! Uniprot P56817 60-447
  8. 1131257Domain d3kn0b_: 3kn0 B: [179466]
    automated match to d1fkna_
    complexed with 3to, tla

Details for d3kn0b_

PDB Entry: 3kn0 (more details), 1.9 Å

PDB Description: structure of bace bound to sch708236
PDB Compounds: (B:) Beta-secretase 1

SCOPe Domain Sequences for d3kn0b_:

Sequence; same for both SEQRES and ATOM records: (download)

>d3kn0b_ b.50.1.2 (B:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyn

SCOPe Domain Coordinates for d3kn0b_:

Click to download the PDB-style file with coordinates for d3kn0b_.
(The format of our PDB-style files is described here.)

Timeline for d3kn0b_: