SCOPe 2.05: Domain d3kl6a_: 3kl6 A:

Lineage for d3kl6a_ (3kl6 A:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Coagulation factor Xa, protease domain [50574] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50575] (55 PDB entries)
   Uniprot P00742 235-467

8. Domain d3kl6a_: 3kl6 A: [179423]
   Other proteins in same PDB: d3kl6b_
   automated match to d1c5md_
   complexed with 443, ca, edo

Details for d3kl6a_

PDB Entry: 3kl6, 1.45 Å

PDB Description: Discovery of Tetrahydropyrimidin-2(1H)-one derivative TAK-442: A potent, selective and orally active factor Xa inhibitor

PDB Compounds: (A:) coagulation factor x heavy chain

SCOPe Domain Sequences for d3kl6a_:

Sequence; same for both SEQRES and ATOM records:

>d3kl6a_ b.47.1.2 (A:) Coagulation factor Xa, protease domain {Human (Homo sapiens) [TaxId: 9606]}
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsm

Timeline for d3kl6a_:

• d3kl6a_ first appeared in SCOPe 2.01
  
• d3kl6a_ appears in SCOPe 2.04
  
• d3kl6a_ appears in SCOPe 2.06
  
• d3kl6a_ appears in the current release, SCOPe 2.08