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Lineage for d3kl6a_ (3kl6 A:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2055629Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2055630Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2055877Family b.47.1.2: Eukaryotic proteases [50514] (49 protein domains)
  6. 2056152Protein Coagulation factor Xa, protease domain [50574] (2 species)
  7. 2056155Species Human (Homo sapiens) [TaxId:9606] [50575] (57 PDB entries)
    Uniprot P00742 235-467
  8. 2056156Domain d3kl6a_: 3kl6 A: [179423]
    Other proteins in same PDB: d3kl6b_
    automated match to d1c5md_
    complexed with 443, ca, edo

Details for d3kl6a_

PDB Entry: 3kl6 (more details), 1.45 Å

PDB Description: Discovery of Tetrahydropyrimidin-2(1H)-one derivative TAK-442: A potent, selective and orally active factor Xa inhibitor
PDB Compounds: (A:) coagulation factor x heavy chain

SCOPe Domain Sequences for d3kl6a_:

Sequence; same for both SEQRES and ATOM records: (download)

>d3kl6a_ b.47.1.2 (A:) Coagulation factor Xa, protease domain {Human (Homo sapiens) [TaxId: 9606]}
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsm

SCOPe Domain Coordinates for d3kl6a_:

Click to download the PDB-style file with coordinates for d3kl6a_.
(The format of our PDB-style files is described here.)

Timeline for d3kl6a_: