SCOPe 2.08: Domain d3k5ua_: 3k5u A:

Lineage for d3k5ua_ (3k5u A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d3k5ua_: 3k5u A: [179104]
   automated match to d1ol5a_
   complexed with pfq

Details for d3k5ua_

PDB Entry: 3k5u, 2.35 Å

PDB Description: identification, sar studies and x-ray cocrystal analysis of a novel furano-pyrimidine aurora kinase a inhibitor

PDB Compounds: (A:) serine/threonine-protein kinase 6

SCOPe Domain Sequences for d3k5ua_:

Sequence, based on SEQRES records:

>d3k5ua_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiq
shlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanals
ychskrvihrdikpenlllgsagelkiadfgwsvhapssrrtdlcgtldylppemiegrm
hdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllk
hnpsqrpmlrevlehpwitansskpsncq

Sequence, based on observed residues (ATOM records):

>d3k5ua_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiq
shlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanals
ychskrvihrdikpenlllgsagelkiadfgwsvhcgtldylppemiegrmhdekvdlws
lgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkhnpsqrpml
revlehpwitansskpsncq

Timeline for d3k5ua_:

• d3k5ua_ first appeared in SCOPe 2.01
  
• d3k5ua_ appears in SCOPe 2.07