SCOPe 2.05: Domain d3jzra_: 3jzr A:

Lineage for d3jzra_ (3jzr A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.42: SWIB/MDM2 domain [47591] (1 superfamily)
   core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
   duplication: consists of two structural repeats

4. Superfamily a.42.1: SWIB/MDM2 domain [47592] (2 families)
   binds to the transactivation domain of human p53

5. Family a.42.1.1: SWIB/MDM2 domain [47593] (5 proteins)
   Pfam PF02201

6. Protein MDM2 [47594] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47596] (46 PDB entries)

8. Domain d3jzra_: 3jzr A: [178935]
   automated match to d1rv1a_

Details for d3jzra_

PDB Entry: 3jzr, 2.1 Å

PDB Description: Human MDM2 liganded with a 12mer peptide inhibitor (pDI6W)

PDB Compounds: (A:) E3 ubiquitin-protein ligase Mdm2

SCOPe Domain Sequences for d3jzra_:

Sequence; same for both SEQRES and ATOM records:

>d3jzra_ a.42.1.1 (A:) MDM2 {Human (Homo sapiens) [TaxId: 9606]}
gsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhiv
ycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvnq

Timeline for d3jzra_:

• d3jzra_ first appeared in SCOPe 2.01
  
• d3jzra_ appears in SCOPe 2.04
  
• d3jzra_ is called d3jzra1 in SCOPe 2.06
  
• d3jzra_ appears in the current release, SCOPe 2.08, called d3jzra1